GSK2033
CAS No. 1221277-90-2
GSK2033 ( —— )
Catalog No. M26703 CAS No. 1221277-90-2
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 87 | Get Quote |
|
10MG | 147 | Get Quote |
|
25MG | 243 | Get Quote |
|
50MG | 389 | Get Quote |
|
100MG | 624 | Get Quote |
|
500MG | 1404 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameGSK2033
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NoteResearch use only, not for human use.
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Brief DescriptionGSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
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DescriptionGSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).(In Vitro):GSK2033 dose-dependently inhibits basal transcription in full-length LXRα or full-length LXRβ cotransfection assays (IC50s: 17 nM and 9 nM, respectively). GSK2033 also effectively inhibits the transcription of an ABCA1 driven luciferase reporter dose-dependently (IC50s: 52 nM for LXRα and 10 nM for LXRβ). GSK2033 also suppresses the expression of both SREBP1 and fatty acid synthase (FASN).(In Vivo):GSK2033 (one month) treatment, does not have obviously effects on hepatic triglyceride levels. GSK2033 treatment also have no effects on plasma triglyceride levels .
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1221277-90-2
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Formula Weight591.7
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Molecular FormulaC29H28F3NO5S2
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Purity>98% (HPLC)
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Solubility——
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SMILESCc1cc(C)c(c(C)c1)S(=O)(=O)N(Cc1ccc(o1)C(F)(F)F)Cc1ccc(cc1)-c1cccc(c1)S(C)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tan KT, et al. Percutaneous sodium tetradecyl sulfate sclerotherapy for peripheral venous vascular malformations: a single-center experience. J Vasc Interv Radiol. 2007;18(3):343-351.
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