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GSK2018682
CAS No. 1034688-30-6
GSK2018682( —— )
Catalog No. M20904 CAS No. 1034688-30-6
GSK2018682 is an agonist of sphingosine-1-phosphate receptor ?(s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 27 | In Stock |
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| 5MG | 42 | In Stock |
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| 10MG | 72 | In Stock |
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| 25MG | 140 | In Stock |
|
| 50MG | 260 | In Stock |
|
| 100MG | 385 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK2018682
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NoteResearch use only, not for human use.
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Brief DescriptionGSK2018682 is an agonist of sphingosine-1-phosphate receptor ?(s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2respectively).
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DescriptionGSK2018682 is an agonist of sphingosine-1-phosphate receptor ?(s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2respectively).(In Vitro):GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4.
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In VitroGSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetS1P Receptor
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RecptorS1P
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Research AreaOthers
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IndicationMultiple sclerosis
Chemical Information
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CAS Number1034688-30-6
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Formula Weight440.88
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Molecular FormulaC22H21ClN4O4
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (283.52 mM)
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SMILESCC(C)Oc1ncc(-c2nc(-c3cccc4c3ccn4CCCC(=O)O)no2)cc1Cl
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Chemical Name4-(4-(5-(5-chloro-6-isopropoxypyridin-3-yl)-124-oxadiazol-3-yl)-1H-indol-1-yl)butanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Xu J Gray F Henderson A et al. Safety pharmacokinetics pharmacodynamics and bioavailability of GSK2018682 a sphingosine-1-phosphate receptor modulator in healthy volunteers[J]. Clinical Pharmacology in Drug Development 2014 3(3):170-178.
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