GSK1904529A ( GSK-4529; GSK1904529a; GSK 1904529; GSK-1904529a )

Catalog No. M10341 CAS No. 1089283-49-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK1904529A
Note

Research use only, not for human use.
Brief Description

GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM.
Description

GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, >100-fold more selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc.
Synonyms

GSK-4529; GSK1904529a; GSK 1904529; GSK-1904529a
Pathway

Angiogenesis
Target

IGF-1R
Recptor

IGF-1R; Insulin Receptor; B-Raf (V600E); Syk; VEGFR2
Research Area

Cancer
Indication

——

CAS Number

1089283-49-7
Formula Weight

851.96
Molecular Formula

C44H47F2N9O5S
Purity

>98%(HPLC)
Solubility

DMSO:124 mg/mL (145.54 mM); Ethanol:<1 mg/mL (<1 mM); Water：<1 mg/mL (<1 mM)
SMILES

O=C(NC1=C(F)C=CC=C1F)C2=CC(C3=C(C4=NC(NC5=CC(CC)=C(N6CCC(N7CCN(S(=O)(C)=O)CC7)CC6)C=C5OC)=NC=C4)N8C=CC=CC8=N3)=CC=C2OC
Chemical Name

N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-(methyloxy)-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-(methyloxy)benzamide

1.Sabbatini P, et al. Clin Cancer Res, 2009, 15(9), 3058-3067.

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