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GSK1059615
CAS No. 958852-01-2
GSK1059615 ( GSK 1059615;GSK-1059615 )
Catalog No. M16846 CAS No. 958852-01-2
GSK1059615 is a highly potent, dual PI3K/mTOR inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 34 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 87 | In Stock |
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| 25MG | 183 | In Stock |
|
| 50MG | 332 | In Stock |
|
| 100MG | 478 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK1059615
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NoteResearch use only, not for human use.
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Brief DescriptionGSK1059615 is a highly potent, dual PI3K/mTOR inhibitor.
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DescriptionGSK1059615 is a highly potent, dual PI3K/mTOR inhibitor with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM for PI3Kα/β/δ/γ and mTOR, respectively; inhibits survival and proliferation of established (SCC-9, SQ20B and A253 lines) and primary human HNSCC cells, blocks PI3K-AKT-mTOR activation in HNSCC cells, induces programmed necrosis but not apoptosis, suppresses SCC-9 tumor growth in nude mice; strongly reduces neutrophil-sperm interaction with IC50 of <10 nM in cattle.Solid Tumors Phase 1 Discontinued
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SynonymsGSK 1059615;GSK-1059615
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptormTOR;PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number958852-01-2
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Formula Weight333.36
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Molecular FormulaC18H11N3O2S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESc1cc2c(cc1/C=C\3/C(=O)NC(=O)S3)c(ccn2)c4ccncc4
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Chemical Name2,4-Thiazolidinedione, 5-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-, (5Z)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Carnero A. et al. Expert Opin Investig Drugs. 2009 Sep;18(9):1265-77.
2. Xie J, et al. Oncotarget. 2017 Feb 7;8(31):50814-50823.
3. Leontieva OV, et al. Aging (Albany NY). 2016 Dec 30;8(12):3535-3551.
4. Hong J, et al. Biol Reprod. 2017 Nov 1;97(5):671-687.
2. Xie J, et al. Oncotarget. 2017 Feb 7;8(31):50814-50823.
3. Leontieva OV, et al. Aging (Albany NY). 2016 Dec 30;8(12):3535-3551.
4. Hong J, et al. Biol Reprod. 2017 Nov 1;97(5):671-687.
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