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GSK1034702

CAS No. 932373-87-0

GSK1034702( GSK-1034702 | GSK 1034702 )

Catalog No. M16671 CAS No. 932373-87-0

GSK1034702 (GSK-1034702) is a potent, allosteric M1 receptor agonist, inhibits binding of [3H]-NMS (0.5 nM) to M1 mAChR with pKi of 6.5.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    GSK1034702
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK1034702 (GSK-1034702) is a potent, allosteric M1 receptor agonist, inhibits binding of [3H]-NMS (0.5 nM) to M1 mAChR with pKi of 6.5.
  • Description
    GSK1034702 (GSK-1034702) is a potent, allosteric M1 receptor agonist, inhibits binding of [3H]-NMS (0.5 nM) to M1 mAChR with pKi of 6.5; improves memory encoding potentially by modulating hippocampal function.Other Indication Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GSK-1034702 | GSK 1034702
  • Pathway
    GPCR/G Protein
  • Target
    mAChR
  • Recptor
    mAChR
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    932373-87-0
  • Formula Weight
    333.407
  • Molecular Formula
    C18H24FN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 2 mg/mL
  • SMILES
    c1ccc2c(c1)c(nn(c2=O)C[C@H]3CCCN3CCCCc4ccc(cc4)OCCCN5CCCCCC5)Cc6ccc(cc6)Cl
  • Chemical Name
    7-fluoro-5-methyl-3-[1-(oxan-4-yl)piperidin-4-yl]-1H-benzimidazol-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nathan PJ, et al. Int J Neuropsychopharmacol. 2013 May;16(4):721-31. 2. Bradley SJ, et al. Mol Pharmacol. 2018 Jun;93(6):645-656.
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