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Home - Products - GPCR/G Protein - Calcium Channel - GSK-7975A

GSK-7975A

CAS No. 1253186-56-9

GSK-7975A( GSK-7975 | GSK7975 )

Catalog No. M11017 CAS No. 1253186-56-9

A selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GSK-7975A
  • Note
    Research use only, not for human use.
  • Brief Description
    A selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM.
  • Description
    A selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM; shows little or no effect on the physiological Ca(2+) spiking evoked by acetylcholine or cholecystokinin; inhibits the release of mast cell mediators and T-cell cytokines from multiple human and rat preparations.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GSK-7975 | GSK7975
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1253186-56-9
  • Formula Weight
    397.305
  • Molecular Formula
    C18H12F5N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 90 mg/mL 226.53 mM
  • SMILES
    O=C(NC1=NN(CC2=CC=C(O)C=C2C(F)(F)F)C=C1)C3=C(F)C=CC=C3F
  • Chemical Name
    2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gerasimenko JV, et al. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13186-91. 2. Rice LV, et al. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57. 3. Derler I, et al. Cell Calcium. 2013 Feb;53(2):139-51.
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