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GSK-7975A
CAS No. 1253186-56-9
GSK-7975A( GSK-7975 | GSK7975 )
Catalog No. M11017 CAS No. 1253186-56-9
A selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
|
| 10MG | 140 | Get Quote |
|
| 25MG | 302 | Get Quote |
|
| 50MG | 488 | Get Quote |
|
| 100MG | 696 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGSK-7975A
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NoteResearch use only, not for human use.
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Brief DescriptionA selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM.
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DescriptionA selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM; shows little or no effect on the physiological Ca(2+) spiking evoked by acetylcholine or cholecystokinin; inhibits the release of mast cell mediators and T-cell cytokines from multiple human and rat preparations.
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In Vitro——
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In Vivo——
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SynonymsGSK-7975 | GSK7975
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1253186-56-9
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Formula Weight397.305
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Molecular FormulaC18H12F5N3O2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 90 mg/mL 226.53 mM
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SMILESO=C(NC1=NN(CC2=CC=C(O)C=C2C(F)(F)F)C=C1)C3=C(F)C=CC=C3F
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Chemical Name2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gerasimenko JV, et al. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13186-91.
2. Rice LV, et al. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57.
3. Derler I, et al. Cell Calcium. 2013 Feb;53(2):139-51.
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