GSK-656 ( GSK656;GSK 656;GSK3036656;GSK-3036656 )

Catalog No. M13395 CAS No. 2131798-13-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK-656
Note

Research use only, not for human use.
Brief Description

GSK-656 (GSK-3036656, GSK656)is a potent, highly selective,orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
Description

GSK-656 (GSK-3036656, GSK656)is a potent, highly selective,orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM; displays no significant activity for human mitochondrial LeuRS and human cytoplasmic LeuRS (IC50>100 uM); shows potent antitubercular activity (Mtb H37Rv IC50=0.08 uM) in vitro; exhibits remarkable PK profiles and efficacy against Mtb in mouse TB infection models.Bacterial Infection Phase 1 Clinical
Synonyms

GSK656;GSK 656;GSK3036656;GSK-3036656
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

Infection
Indication

Bacterial Infection

CAS Number

2131798-13-3
Formula Weight

293.94
Molecular Formula

C10H14BCl2NO4
Purity

>98% (HPLC)
Solubility

DMSO : 67.5 mg/mL 229.64 mM
SMILES

B1(C2=C(C=CC(=C2C(O1)CN)Cl)OCCO)O.Cl
Chemical Name

(S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c]-[1,2]oxaborol-1(3H)-ol hydrochloride

1. Li X,et al. J Med Chem. 2017 Oct 12;60(19):8011-8026.

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