GSK-2982772 ( GSK2982772 )

Catalog No. M12391 CAS No. 1622848-92-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK-2982772
Note

Research use only, not for human use.
Brief Description

GSK-2982772 is a potent, selective, ATP competitive RIP1 kinase inhibitor with IC50 of 16 nM.
Description

GSK-2982772 is a potent, selective, ATP competitive RIP1 kinase inhibitor with IC50 of 16 nM; inhibits RIP1-dependent inflammatory cytokine MIP-1β production in human whole blood with IC50 of 0.5 nM, reduces spontaneous production of cytokines (IL-1β and IL-6) in a concentration-dependent fashion from ulcerative colitis explant tissue; shows potential for the treatment of inflammatory diseases in vivo.Psoriasis Phase 2 Clinical
Synonyms

GSK2982772
Pathway

Apoptosis
Target

RIP kinase
Recptor

RIP kinase
Research Area

Inflammation/Immunology
Indication

Psoriasis

CAS Number

1622848-92-3
Formula Weight

377.40
Molecular Formula

C20H19N5O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 264.97 mM
SMILES

CN1C2=CC=CC=C2OCC(C1=O)NC(=O)C3=NNC(=N3)CC4=CC=CC=C4
Chemical Name

(S)-3-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide

1. Harris PA, et al. J Med Chem. 2017 Feb 23;60(4):1247-1261.
2. Weisel K, et al. Pharmacol Res Perspect. 2017 Dec;5(6).

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