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GSK-1482160
CAS No. 1001389-72-5
GSK-1482160( —— )
Catalog No. M35501 CAS No. 1001389-72-5
GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 46 | Get Quote |
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| 10MG | 72 | Get Quote |
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| 25MG | 144 | Get Quote |
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| 50MG | 255 | Get Quote |
|
| 100MG | 357 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGSK-1482160
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NoteResearch use only, not for human use.
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Brief DescriptionGSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity.
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DescriptionGSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetP2X Receptor
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RecptorP2X Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1001389-72-5
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Formula Weight334.72
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Molecular FormulaC14H14ClF3N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (298.76 mM; Ultrasonic )
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SMILESCN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ali Z, et al. Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects. Br J Clin Pharmacol. 2013;75(1):197-207. doi:10.1111/j.1365-2125.2012.04320.x
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