GS-143 ( GS 143; GS143 )

Catalog No. M24964 CAS No. 916232-21-8

GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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2MG	49	In Stock
5MG	80	In Stock
10MG	126	In Stock
25MG	259	In Stock
50MG	410	In Stock
100MG	609	In Stock
500MG	1287	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

GS-143
Note

Research use only, not for human use.
Brief Description

GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation.
Description

GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect
Synonyms

GS 143; GS143
Pathway

Others
Target

Other Targets
Recptor

IκBα?phosphorylation
Research Area

——
Indication

——

Chemical Information

CAS Number

916232-21-8
Formula Weight

466.5
Molecular Formula

C28H19FN2O4
Purity

>98% (HPLC)
Solubility

DMSO:40 mg/mL?(85.75 mM;?Need ultrasonic)
SMILES

OC(c(cc1)ccc1N(C1=O)N=C(Cc2ccccc2)C1=Cc1ccc(-c(cccc2)c2F)o1)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Rashmi BS, Gayathri D. Molecular characterization of gluten hydrolysing Bacillus sp. and their efficacy and biotherapeutic potential as probiotics using Caco-2 cell line. J Appl Microbiol. 2017 Sep;123(3):759-772. doi: 10.1111/jam.13517. Epub 2017 Aug 4. PubMed PMID: 28637081.

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