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GS-143

CAS No. 916232-21-8

GS-143 ( GS 143; GS143 )

Catalog No. M24964 CAS No. 916232-21-8

GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 49 In Stock
5MG 80 In Stock
10MG 126 In Stock
25MG 259 In Stock
50MG 410 In Stock
100MG 609 In Stock
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Biological Information

  • Product Name
    GS-143
  • Note
    Research use only, not for human use.
  • Brief Description
    GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation.
  • Description
    GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect
  • Synonyms
    GS 143; GS143
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    IκBα?phosphorylation
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    916232-21-8
  • Formula Weight
    466.5
  • Molecular Formula
    C28H19FN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:40 mg/mL?(85.75 mM;?Need ultrasonic)
  • SMILES
    OC(c(cc1)ccc1N(C1=O)N=C(Cc2ccccc2)C1=Cc1ccc(-c(cccc2)c2F)o1)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rashmi BS, Gayathri D. Molecular characterization of gluten hydrolysing Bacillus sp. and their efficacy and biotherapeutic potential as probiotics using Caco-2 cell line. J Appl Microbiol. 2017 Sep;123(3):759-772. doi: 10.1111/jam.13517. Epub 2017 Aug 4. PubMed PMID: 28637081.
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