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GRK6-IN-2
CAS No. 2677786-27-3
GRK6-IN-2( —— )
Catalog No. M35570 CAS No. 2677786-27-3
GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 92 | Get Quote |
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| 10MG | 155 | Get Quote |
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| 25MG | 296 | Get Quote |
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| 50MG | 457 | Get Quote |
|
| 100MG | 672 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGRK6-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionGRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.
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DescriptionGRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetGRK (GPCRK)
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RecptorGRK
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Research Area——
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Indication——
Chemical Information
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CAS Number2677786-27-3
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Formula Weight376.43
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Molecular FormulaC21H21FN6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?Methanol : ≥ 125 mg/mL (332.07 mM)DMSO : ≥ 100 mg/mL (265.65 mM)
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SMILESCCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3ccccc23)n[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147.?
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