GR-79236

CAS No. 124555-18-6

GR-79236( GR-79236X | GR79236 )

Catalog No. M10993 CAS No. 124555-18-6

A potent and selective Adenosine A1 receptor agonist with Ki of 3.1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 141 Get Quote
50MG 564 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    GR-79236
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective Adenosine A1 receptor agonist with Ki of 3.1 nM.
  • Description
    A potent and selective Adenosine A1 receptor agonist with Ki of 3.1 nM; exerts profound antilipolytic effects with minimal effects on blood pressure and heart rate; orally active.
  • In Vitro
    GR79236 inhibits Isoprenaline-stimulated cAMP accumulation in DDT-MF2 cells with an IC50 of 2.6 nM. GR79236 inhibits catecholamine-induced lipolysis in human, rat and dog isolated adipocytes.
  • In Vivo
    GR79236 decreases locomotor activity and inhibits DMCM-induced seizures in mice (ED50s of 0.13 mg/kg and 0.3 mg/kg, respectively). Oral administration of GR79236 (0.1-10 mg/kg) to fed rats induces minimal changes in the plasma concentration of non-esterified fatty acids and in the blood concentrations of glucose and lactate. Intravenous infusion of GR79236 to fasted pithed rats, or oral administration of GR79236 to fasted conscious rats and dogs, produces time- and dose-dependent decreases in the plasma non-esterified fatty acid concentration. In the fasted rats, doses of GR79236 that lowered plasma levels of non-esterified fatty acids also produced hypotriglyceridaemia and anti-ketotic effects.
  • Synonyms
    GR-79236X | GR79236
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    124555-18-6
  • Formula Weight
    351.3577
  • Molecular Formula
    C15H21N5O5
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: ≥ 100 mg/mL
  • SMILES
    O[C@H]1[C@H](N2C=NC3=C(N[C@@H]4[C@@H](O)CCC4)N=CN=C23)O[C@H](CO)[C@H]1O
  • Chemical Name
    Adenosine, N-[(1S,2S)-2-hydroxycyclopentyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gardner CJ, et al. Eur J Pharmacol. 1994 May 12;257(1-2):117-21. 2. Webster JM, et al. Biochim Biophys Acta. 1996 Jun 7;1316(2):109-13.
molnova catalog
related products
  • DL-Norepinephrine hy...

    DL-Norepinephrine hydrochloride is a high-affinity basic amino acid substrate of amino acid transporter b0 + with a Km value in the range of 100-400 μM.

  • Preladenant

    A potent and highly selective A2A receptor competitive antagonist with Ki of 1.1 nM.

  • Methyl protocatechua...

    Thermographic recording material with improved image tone