
GR-79236
CAS No. 124555-18-6
GR-79236( GR-79236X | GR79236 )
Catalog No. M10993 CAS No. 124555-18-6
A potent and selective Adenosine A1 receptor agonist with Ki of 3.1 nM.
Purity : >98% (HPLC)






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10MG | 141 | Get Quote |
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50MG | 564 | Get Quote |
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Biological Information
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Product NameGR-79236
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective Adenosine A1 receptor agonist with Ki of 3.1 nM.
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DescriptionA potent and selective Adenosine A1 receptor agonist with Ki of 3.1 nM; exerts profound antilipolytic effects with minimal effects on blood pressure and heart rate; orally active.
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In VitroGR79236 inhibits Isoprenaline-stimulated cAMP accumulation in DDT-MF2 cells with an IC50 of 2.6 nM. GR79236 inhibits catecholamine-induced lipolysis in human, rat and dog isolated adipocytes.
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In VivoGR79236 decreases locomotor activity and inhibits DMCM-induced seizures in mice (ED50s of 0.13 mg/kg and 0.3 mg/kg, respectively). Oral administration of GR79236 (0.1-10 mg/kg) to fed rats induces minimal changes in the plasma concentration of non-esterified fatty acids and in the blood concentrations of glucose and lactate. Intravenous infusion of GR79236 to fasted pithed rats, or oral administration of GR79236 to fasted conscious rats and dogs, produces time- and dose-dependent decreases in the plasma non-esterified fatty acid concentration. In the fasted rats, doses of GR79236 that lowered plasma levels of non-esterified fatty acids also produced hypotriglyceridaemia and anti-ketotic effects.
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SynonymsGR-79236X | GR79236
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorAdenosine Receptor
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number124555-18-6
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Formula Weight351.3577
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Molecular FormulaC15H21N5O5
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 100 mg/mL
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SMILESO[C@H]1[C@H](N2C=NC3=C(N[C@@H]4[C@@H](O)CCC4)N=CN=C23)O[C@H](CO)[C@H]1O
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Chemical NameAdenosine, N-[(1S,2S)-2-hydroxycyclopentyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gardner CJ, et al. Eur J Pharmacol. 1994 May 12;257(1-2):117-21.
2. Webster JM, et al. Biochim Biophys Acta. 1996 Jun 7;1316(2):109-13.
molnova catalog



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