GPR183( 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide )

Catalog No. M28998 CAS No. 1241280-25-0

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Product Name

GPR183
Note

Research use only, not for human use.
Brief Description

GPR183 is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholesterol (7α,25-OHC). GPR183 can be used in research on inflammatory bowel disease (IBD).
Description

GPR183 is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholesterol (7α,25-OHC). GPR183 can be used in research on inflammatory bowel disease (IBD).
In Vitro

SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC50 value below 50 nM. Cell Viability Assay Cell Line:The human leukemia (HL)-60 cells Concentration:5×of the antagonist Incubation Time:15 min Result:Had GPR183-specific (IC50: 28.5nM) and abolished 7a, 25-OHC–induced calcium mobilization in the HL-60 cells.
In Vivo

SAE-14 (compound SAE-14) (i.th.; 2.9 μM; once) can reverse nerve injury-induced allodynia in mice. Animal Model:Male and female ICR mice Dosage:2.9 μM Administration:intrathecal (i.th.) injections; 2.9 μM; once Result:Reversed CCI-induced mechanical allodynia in a time-dependent manner.
Synonyms

3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide
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