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GNF4877
CAS No. 2041073-22-5
GNF4877 ( —— )
Catalog No. M23913 CAS No. 2041073-22-5
GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6?nM and 16?nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 520 | In Stock |
|
| 10MG | 822 | In Stock |
|
| 25MG | 1557 | In Stock |
|
| 50MG | 2673 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNF4877
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NoteResearch use only, not for human use.
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Brief DescriptionGNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6?nM and 16?nM).
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DescriptionGNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6?nM and 16?nM). It?leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGSK3β;DYRK1A
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Research Area——
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Indication——
Chemical Information
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CAS Number2041073-22-5
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Formula Weight494.5
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Molecular FormulaC25H27FN6O4
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Purity>98% (HPLC)
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SolubilityDMSO:4.17 mg/mL (8.43 mM; Need ultrasonic and warming)
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SMILESCC(C)OC1=CC(=C(C=C1)F)C2=CN=C(C(=N2)C(=O)NC3=C(C=CN=C3)N4CCC[C@H](C4)C(=O)O)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shen W, et al. Inhibition of DYRK1A and GSK3β induces human β-cell proliferation. Nat Commun. 2015 Oct 26;6:8372.
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