GNF-5837

CAS No. 1033769-28-6

GNF-5837 ( GNF5837; GNF-5837; GNF 5837 )

Catalog No. M17764 CAS No. 1033769-28-6

GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 39 In Stock
10MG 69 In Stock
25MG 113 In Stock
50MG 178 In Stock
100MG 295 In Stock
200MG 383 In Stock
500MG 623 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    GNF-5837
  • Note
    Research use only, not for human use.
  • Brief Description
    GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
  • Description
    GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. The properties of GNF-5837 make it a good tool for the elucidation of TRK biology in cancer and other nononcology indications.
  • Synonyms
    GNF5837; GNF-5837; GNF 5837
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Kit; PDGFRβ; TrkA; TrkB; TrkC
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1033769-28-6
  • Formula Weight
    535.49
  • Molecular Formula
    C28H21F4N5O2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 32 mg/mL; 59.76 mM
  • SMILES
    Cc1c(cc(cc1)NC(=O)Nc1c(ccc(c1)C(F)(F)F)F)Nc1cc2c(cc1)/C(=C/c1ccc[nH]1)/C(=O)N2
  • Chemical Name
    (Z)-1-(3-((3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Albaugh P, et al. ACS Med Chem Lett. 2012, 3(2), 140-145.
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