GNF-5837
CAS No. 1033769-28-6
GNF-5837 ( GNF5837; GNF-5837; GNF 5837 )
Catalog No. M17764 CAS No. 1033769-28-6
GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 39 | In Stock |
|
10MG | 69 | In Stock |
|
25MG | 113 | In Stock |
|
50MG | 178 | In Stock |
|
100MG | 295 | In Stock |
|
200MG | 383 | In Stock |
|
500MG | 623 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNF-5837
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NoteResearch use only, not for human use.
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Brief DescriptionGNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
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DescriptionGNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. The properties of GNF-5837 make it a good tool for the elucidation of TRK biology in cancer and other nononcology indications.
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SynonymsGNF5837; GNF-5837; GNF 5837
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PathwayOthers
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TargetOther Targets
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RecptorKit; PDGFRβ; TrkA; TrkB; TrkC
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1033769-28-6
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Formula Weight535.49
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Molecular FormulaC28H21F4N5O2
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Purity98%
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SolubilityDMSO : ≥ 32 mg/mL; 59.76 mM
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SMILESCc1c(cc(cc1)NC(=O)Nc1c(ccc(c1)C(F)(F)F)F)Nc1cc2c(cc1)/C(=C/c1ccc[nH]1)/C(=O)N2
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Chemical Name(Z)-1-(3-((3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Albaugh P, et al. ACS Med Chem Lett. 2012, 3(2), 140-145.
molnova catalog
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