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GNE-0877
CAS No. 1374828-69-9
GNE-0877( GNE0877 )
Catalog No. M11549 CAS No. 1374828-69-9
GNE-7915 is a highly potent, selective, brain-penetrating LRRK2 inhibitor with Ki of 0.6 nM (LRRK2 G2019S), pLRRK2 cell IC50 of 3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 92 | In Stock |
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| 2MG | 52 | In Stock |
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| 5MG | 116 | In Stock |
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| 10MG | 187 | In Stock |
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| 25MG | 376 | In Stock |
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| 50MG | 551 | In Stock |
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| 100MG | 786 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1609 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNE-0877
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-7915 is a highly potent, selective, brain-penetrating LRRK2 inhibitor with Ki of 0.6 nM (LRRK2 G2019S), pLRRK2 cell IC50 of 3 nM.
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DescriptionGNE-7915 is a highly potent, selective, brain-penetrating LRRK2 inhibitor with Ki of 0.6 nM (LRRK2 G2019S), pLRRK2 cell IC50 of 3 nM; induces abnormal cytoplasmic accumulation of secretory lysosome-related organelles known as lamellar bodies in type II pneumocytes of the lung in nonhuman primates, but no lysosomal abnormality in the kidney.
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In VitroGNE0877 (1 μM; 10-30 min) shows good cellular potency in human liver microsomes and hepatocytes.Cell Viability Assay Cell Line:Human liver microsomes and hepatocytes Concentration:1 μM Incubation Time:10, 20 and 30 min Result:Exibited low turnover and good vitro stability in human liver microsomes and hepatocytes with no glucuronidation.
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In VivoGNE0877 (10 and 50 mg/kg; i.p. once) inhibits LRRK2 Ser1292 autophosphorylation. Animal Model:BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation Dosage:10 and 50 mg/kg Administration:Intraperitoneal injection; 10 and 50 mg/kg once Result:Tration-dependently inhibited Ser1292 autophosphorylation with an IC50 of 3 nM.
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SynonymsGNE0877
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PathwayAutophagy
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TargetLRRK2
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RecptorLRRK2
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number1374828-69-9
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Formula Weight339.326
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Molecular FormulaC14H16F3N7
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Purity>98% (HPLC)
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SolubilityDMSO: 62 mg/mL (182.7 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESCC(N1N=C(C)C(NC2=NC=C(C(F)(F)F)C(NC)=N2)=C1)(C)C#N
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Chemical Name2-methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanenitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fuji RN, et al. Sci Transl Med. 2015 Feb 4;7(273):273ra15.
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