GLPG-0492( GLPG0492 )

Catalog No. M10803 CAS No. 1215085-92-9

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Product Name

GLPG-0492
Note

Research use only, not for human use.
Brief Description

A novel, orally active, non-steroidal selective androgen receptor modulator (SARM) with in vitro potency of 13 nM.
Description

A novel, orally active, non-steroidal selective androgen receptor modulator (SARM) with in vitro potency of 13 nM; exhibits anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate in a classical model of orchidectomized rat; shows a potential treatment for Duchenne muscular dystrophy (DMD).Other Indication Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

GLPG0492
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

Androgen Receptor (AR)
Research Area

Other Indications
Indication

Other Disease

CAS Number

1215085-92-9
Formula Weight

389.328
Molecular Formula

C19H14F3N3O3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

N#CC1=CC=C(N(C(N(C)[C@]2(CO)C3=CC=CC=C3)=O)C2=O)C=C1C(F)(F)F
Chemical Name

Benzonitrile, 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-

1. Nique F, et al. J Med Chem. 2012 Oct 11;55(19):8236-47. 2. Cozzoli A, et al. Pharmacol Res. 2013 Jun;72:9-24.

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