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GLPG-0187

CAS No. 1320346-97-1

GLPG-0187 ( GLPG 0187;GLPG0187 )

Catalog No. M11294 CAS No. 1320346-97-1

GLPG-0187 (GLPG0187) is a highly potent, broad spectrum integrin receptor antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 95 In Stock
10MG 140 In Stock
25MG 237 In Stock
50MG 350 In Stock
100MG 521 In Stock
500MG 1134 In Stock
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Biological Information

  • Product Name
    GLPG-0187
  • Note
    Research use only, not for human use.
  • Brief Description
    GLPG-0187 (GLPG0187) is a highly potent, broad spectrum integrin receptor antagonist.
  • Description
    GLPG-0187 (GLPG0187) is a highly potent, broad spectrum integrin receptor antagonist with IC50 of 1-10 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1; significantly inhibits angiogenesis both in vivo and in vitro, osteoclastogenesis in vitro, and bone loss in vivo; inhibits de novo formation and progression of bone and visceral metastases in prostate cancer and breast cancer mice models.Solid Tumors Phase 1 Clinical
  • Synonyms
    GLPG 0187;GLPG0187
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    αvβ1integrin
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    1320346-97-1
  • Formula Weight
    595.71
  • Molecular Formula
    C29H37N7O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 15 mg/mL
  • SMILES
    O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC=C(OC)C=C5)=O
  • Chemical Name
    L-Alanine, 3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pujuguet P, et al. Eur J Cancer. 2011;47:S28. doi: 10.1016/S0959-8049(11)72695-8.
2. Cirkel GA, et al. Invest New Drugs. 2016 Apr;34(2):184-92.
3. van der Horst G, et al. Neoplasia. 2011 Jun;13(6):516-25.
4. Reeves KJ, et al. Int J Cancer. 2015 Apr 1;136(7):1731-40.
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