GLP-1(7-37)

Research use only, not for human use.

GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells.

GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells.(In Vivo):GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats. Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM.

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GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats.Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM. Animal Model:Male Sprague-Dawley rats weighing 300 to 350 g with maintained plasma glucose concentration at 11 mM.Dosage:0.5, 5 or 50 pmol/min/kg.Administration:IV during the second hour of a 2-hour 11-mmol/L hyperglycemic clamp.Result:Produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion.Animal Model:Male Sprague-Dawley rats weighing 300 to 350 g with glucose IV at a variable.rate for 7 hours to maintain plasma glucose concentration at 11 mM.Dosage:5 pmol/min/kg.Administration:IV from 1 hour through 7 hours.Result:Produced a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle.

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GPCR/G Protein

Glucagon Receptor

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106612-94-6

3355.67

C151H228N40O47

>98% (HPLC)

H2O : 30 mg/mL (8.94 mM; Need ultrasonic and warming)

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Sequence:His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly

(-20℃)

With Ice Pack

≥ 2 years