GLN-1062

CAS No. 224169-27-1

GLN-1062( Memogain )

Catalog No. M26751 CAS No. 224169-27-1

GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 140 Get Quote
10MG 222 Get Quote
25MG 448 Get Quote
50MG 653 Get Quote
100MG 888 Get Quote
500MG 1782 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    GLN-1062
  • Note
    Research use only, not for human use.
  • Brief Description
    GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain.
  • Description
    GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain.(In Vivo):GLN-1062 has more than 15-fold higher bioavailability in the brain than the same doses of galantamine. In animal models of drug-induced amnesia, GLN-1062 produced several fold larger cognitive improvement than the same doses of galantamine, without exhibiting any significant levels of gastrointestinal side effects that are typical for the unmodified drug and other inhibitors of cholinesterases, such as donepezil and rivastigmin. In the ferret, dramatically reduced emetic and behavioral responses were observed when GLN-1062 was administered instead of galantamine.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Memogain
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Farnesyl transferase (FTase)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    224169-27-1
  • Formula Weight
    391.467
  • Molecular Formula
    C24H25NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (255.45 mM)
  • SMILES
    [H][C@]12C[C@@H](OC(=O)c3ccccc3)C=C[C@]11CCN(C)Cc3ccc(OC)c(O2)c13
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Stacy L Moulder, et al. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10(21):7127-35.
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