GJ103 sodium salt( GJ 103 sodium salt | GJ-103 sodium salt )

Catalog No. M11982 CAS No. 1459687-96-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

GJ103 sodium salt
Note

Research use only, not for human use.
Brief Description

A novel small molecular read-through (SMRT) compound that can induce read through of nonsense mutations in the ATM gene.
Description

A novel small molecular read-through (SMRT) compound that can induce read through of nonsense mutations in the ATM gene; induces ATM kinase on both TGA and TAG stop codons and restores ATMpSer1981 autophosphorylation and SMC1pSer966 transphosphorylation in A-T cells.
In Vitro

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In Vivo

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Synonyms

GJ 103 sodium salt | GJ-103 sodium salt
Pathway

Cell Cycle/DNA Damage
Target

ATM/ATR
Recptor

ATM
Research Area

Other Indications
Indication

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CAS Number

1459687-96-7
Formula Weight

364.35418928
Molecular Formula

C16H13N4NaO3S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 34 mg/mL
SMILES

COC1=CC=CC(=C1)N2C(=NN=C2SCC(=O)[O-])C3=CC=CC=N3.[Na+]
Chemical Name

Acetic acid, 2-[[4-(3-methoxyphenyl)-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-, sodium salt (1:1)

1. Du L, et al. Mol Ther. 2013 Sep;21(9):1653-60.

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