GFB-8438 ( —— )

Catalog No. M21995 CAS No. 2304549-73-1

GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

GFB-8438
Note

Research use only, not for human use.
Brief Description

GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).
Description

GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively). GFB-8438 is a novel TRPC5 inhibitor.?GFB-8438 protects mouse podocytes from injury induced by protamine sulfate (PS) in vitro.GFB-8438?is also efficacious in a hypertensive deoxycorticosterone acetate (DOCA)-salt rat model of FSGS, significantly reducing both total protein and albumin concentrations in urine.
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

TRPC5
Research Area

——
Indication

——

Chemical Information

CAS Number

2304549-73-1
Formula Weight

386.75
Molecular Formula

C16H14ClF3N4O2
Purity

>98% (HPLC)
Solubility

——
SMILES

FC(F)(F)C1=CC=CC=C1CN1CCN(CC1=O)C1=C(Cl)C(=O)NN=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Yu M, et al.Discovery?of a?Potent?and?Selective?TRPC5?Inhibitor,?Efficacious?in a?Focal?Segmental?Glomerulosclerosis?Model.ACS Med Chem Lett.?2019 Oct 22;10(11):1579-1585.

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