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GFB-8438
CAS No. 2304549-73-1
GFB-8438 ( —— )
Catalog No. M21995 CAS No. 2304549-73-1
GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | Get Quote |
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| 5MG | 87 | Get Quote |
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| 10MG | 140 | Get Quote |
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| 25MG | 228 | Get Quote |
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| 50MG | 320 | Get Quote |
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| 100MG | 476 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGFB-8438
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NoteResearch use only, not for human use.
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Brief DescriptionGFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).
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DescriptionGFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively). GFB-8438 is a novel TRPC5 inhibitor.?GFB-8438 protects mouse podocytes from injury induced by protamine sulfate (PS) in vitro.GFB-8438?is also efficacious in a hypertensive deoxycorticosterone acetate (DOCA)-salt rat model of FSGS, significantly reducing both total protein and albumin concentrations in urine.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRPC5
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Research Area——
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Indication——
Chemical Information
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CAS Number2304549-73-1
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Formula Weight386.75
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Molecular FormulaC16H14ClF3N4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESFC(F)(F)C1=CC=CC=C1CN1CCN(CC1=O)C1=C(Cl)C(=O)NN=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yu M, et al.Discovery?of a?Potent?and?Selective?TRPC5?Inhibitor,?Efficacious?in a?Focal?Segmental?Glomerulosclerosis?Model.ACS Med Chem Lett.?2019 Oct 22;10(11):1579-1585.
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