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GDC046

CAS No. 1258292-64-6

GDC046( —— )

Catalog No. M22623 CAS No. 1258292-64-6

GDC046, a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.

GDC046, a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GDC046
  • Note
    Research use only, not for human use.
  • Brief Description
    GDC046, a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
  • Description
    GDC046, a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
  • In Vitro
    In cell-based assays, GDC-046 demonstrates reasonable potency in blocking the IL-12 pathway (IL-12 pSTAT4 EC50=380 nM) while displaying less activity in the EPO (JAK2) pathway (EPO pSTAT5 EC50=1700 nM) and IL-6 (JAK1) pathway (IL-6 pSTAT3 EC50=2000 nM).
  • In Vivo
    In mice, GDC-046 exhibits relatively high clearance (65 mL/min/kg) when dosed intravenously (i.v. 1 mg/kg) and exhibits modest oral exposure (AUC=2.6 μM·h at p.o. 5 mg/kg).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1258292-64-6
  • Formula Weight
    350.2
  • Molecular Formula
    C16H13Cl2N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (178.47 mM)
  • SMILES
    Clc1cccc(Cl)c1C(=O)Nc1ccnc(NC(=O)C2CC2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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