
GDC-0339
CAS No. 1428569-85-0
GDC-0339( GDC-0339 | GDC 0339 | GDC0339 )
Catalog No. M11806 CAS No. 1428569-85-0
GDC-0339 is a novel small molecule pan-Pim kinase inhibitor that was discovered as a potential treatment for multiple myeloma.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 374 | Get Quote |
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50MG | 1935 | Get Quote |
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100MG | 3357 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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Biological Information
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Product NameGDC-0339
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NoteResearch use only, not for human use.
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Brief DescriptionGDC-0339 is a novel small molecule pan-Pim kinase inhibitor that was discovered as a potential treatment for multiple myeloma.
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DescriptionGDC-0339 is a novel small molecule pan-Pim kinase inhibitor that was discovered as a potential treatment for multiple myeloma.Blood Cancer Preclinical.
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In VitroGDC-0339 is cytostatic, with an IC50 of 0.1 μM for MM.1S cells.GDC-0339 treatment reveals a constellation of Pim downstream signaling events consistent with inhibition of Pim kinases. Cell Viability Assay Cell Line:MM.1S cells Concentration:Incubation Time:3 days Result:Inhibited cell viability.Western Blot Analysis Cell Line:MM.1S cells Concentration:0.01 μM, 0.03 μM, 0.09 μM,0.27 μM, 0.83 μM, 2.5 μM Incubation Time:4 hours Result:Induced a constellation of Pim downstream signaling events consistent with inhibition of Pim kinases.
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In VivoGDC-0339 (1-300 mg/kg; p.o; daily; for 21 days) is efficacious in RPMI8226 and MM.1S human multiple myeloma xenograft mouse models.GDC-0339 has a half-life of t1/2=0.9 h. Animal Model:Female C.B-17 SCID mice, RPMI8226 human multiple myeloma xenograft mouse model Dosage:1mg/kg, 10 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg, 300 mg/kg Administration:Oral administration; once daily; for 21 days Result:Showed dose-dependent tumor growth inhibition.
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SynonymsGDC-0339 | GDC 0339 | GDC0339
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PathwayJAK/STAT Signaling
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TargetPim
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RecptorPim
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1428569-85-0
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Formula Weight465.4952
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Molecular FormulaC20H22F3N7OS
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 52 mg/mL
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SMILESO=C(C1=C(N)SC(C2=C(F)C=CC=C2F)=N1)NC3=C(N4CC[C@@H](N)[C@H](F)CC4)N(C)N=C3
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Chemical Name4-Thiazolecarboxamide, 5-amino-N-[5-[(4R,5R)-4-amino-5-fluorohexahydro-1H-azepin-1-yl]-1-methyl-1H-pyrazol-4-yl]-2-(2,6-difluorophenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Takahashi RH, et al. Drug Metab Dispos. 2017 Aug 8. pii: dmd.117.076786.
molnova catalog



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