GDC-0032 ( Taselisib )

Catalog No. M11159 CAS No. 1282512-48-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GDC-0032
Note

Research use only, not for human use.
Brief Description

GDC-0032 is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with IC50 of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ.
Description

GDC-0032 is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with IC50 of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ.
Synonyms

Taselisib
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Research Area

Cancer
Indication

——

CAS Number

1282512-48-4
Formula Weight

460.53
Molecular Formula

C24H28N8O2
Purity

>98%(HPLC)
Solubility

Ethanol: 7 mg/mL warmed (15.19 mM); DMSO: 70 mg/mL warmed (151.99 mM)
SMILES

CC(C)(N1N=CC(C2=CC=C3C4=NC(C5=NC(C)=NN5C(C)C)=CN4CCOC3=C2)=C1)C(N)=O
Chemical Name

2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide

1.Ndubaku CO, et al. J Med Chem. 2013 Jun 13; 56(11): 4597-610.

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