GBT-440
CAS No. 1446321-46-5
GBT-440 ( GBT 440;GBT440;Voxelotor )
Catalog No. M11895 CAS No. 1446321-46-5
A new potent allosteric effector of sickle cell hemoglobin; increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 46 | Get Quote |
|
10MG | 67 | Get Quote |
|
25MG | 110 | Get Quote |
|
50MG | 178 | Get Quote |
|
100MG | 332 | Get Quote |
|
200MG | 494 | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameGBT-440
-
NoteResearch use only, not for human use.
-
Brief DescriptionA new potent allosteric effector of sickle cell hemoglobin; increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions.
-
DescriptionA new potent allosteric effector of sickle cell hemoglobin; increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions; orally bioavailable and partitions highly and favorably into the red blood cell with a RBC/plasma ratio of ~150.Anemia Phase 3 Clinical
-
SynonymsGBT 440;GBT440;Voxelotor
-
PathwayOthers
-
TargetOther Targets
-
RecptorOther Targets
-
Research AreaOther Indications
-
IndicationAnemia
Chemical Information
-
CAS Number1446321-46-5
-
Formula Weight337.37
-
Molecular FormulaC19H19N3O3
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=CC1=C(OCC2=CC=CN=C2C3=CC=NN3C(C)C)C=CC=C1O
-
Chemical NameBenzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Metcalf B, et al. ACS Med Chem Lett. 2017 Jan 23;8(3):321-326.
2. Oksenberg D, et al. Br J Haematol. 2016 Oct;175(1):141-53.
3. Dufu K, et al. Hematol Rep. 2016 Sep 28;8(3):6637.
2. Oksenberg D, et al. Br J Haematol. 2016 Oct;175(1):141-53.
3. Dufu K, et al. Hematol Rep. 2016 Sep 28;8(3):6637.
molnova catalog
related products
-
(S,R,S)-AHPC-Me
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771.
-
Buddlejasaponin IV
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-kappaB activation.
-
Crocin (Gardenia Fru...
Crocin is a water-soluble carotenoid pigment of saffron (Crocus sativus L.). Crocin has anti-inflammatory anti-oxidative anti-apoptotic anti-asthma anti-cancer and hypolipidemic effects.