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GBT-440

CAS No. 1446321-46-5

GBT-440 ( GBT 440;GBT440;Voxelotor )

Catalog No. M11895 CAS No. 1446321-46-5

A new potent allosteric effector of sickle cell hemoglobin; increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 67 Get Quote
25MG 110 Get Quote
50MG 178 Get Quote
100MG 332 Get Quote
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Biological Information

  • Product Name
    GBT-440
  • Note
    Research use only, not for human use.
  • Brief Description
    A new potent allosteric effector of sickle cell hemoglobin; increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions.
  • Description
    A new potent allosteric effector of sickle cell hemoglobin; increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions; orally bioavailable and partitions highly and favorably into the red blood cell with a RBC/plasma ratio of ～150.Anemia Phase 3 Clinical
  • Synonyms
    GBT 440;GBT440;Voxelotor
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Anemia

Chemical Information

  • CAS Number
    1446321-46-5
  • Formula Weight
    337.37
  • Molecular Formula
    C19H19N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=CC1=C(OCC2=CC=CN=C2C3=CC=NN3C(C)C)C=CC=C1O
  • Chemical Name
    Benzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Metcalf B, et al. ACS Med Chem Lett. 2017 Jan 23;8(3):321-326.
2. Oksenberg D, et al. Br J Haematol. 2016 Oct;175(1):141-53.
3. Dufu K, et al. Hematol Rep. 2016 Sep 28;8(3):6637.
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