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Home - Products - GPCR/G Protein - Cannabinoid Receptor - GAT-211

GAT-211

CAS No. 102704-40-5

GAT-211( GAT211 )

Catalog No. M10132 CAS No. 102704-40-5

GAT-211 (GAT211) is a selective cannabinoid 1 receptor (CB1R) positive allosteric modulator with pKb of 7.26, Arrestin2 EC50 of 775 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GAT-211
  • Note
    Research use only, not for human use.
  • Brief Description
    GAT-211 (GAT211) is a selective cannabinoid 1 receptor (CB1R) positive allosteric modulator with pKb of 7.26, Arrestin2 EC50 of 775 nM.
  • Description
    GAT-211 (GAT211) is a selective cannabinoid 1 receptor (CB1R) positive allosteric modulator with pKb of 7.26, Arrestin2 EC50 of 775 nM; engages CB1R allosteric site(s), enhances the binding of the orthosteric full agonist [3H]CP55,490, and reduces the binding of the orthosteric antagonist/inverse agonist [3H]SR141716A; displayed both PAM and agonist activity in HEK293A and Neuro2a cells expressing human recombinant CB1R (hCB1R) and in mouse-brain membranes rich in native CB1R.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GAT211
  • Pathway
    GPCR/G Protein
  • Target
    Cannabinoid Receptor
  • Recptor
    Cannabinoid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    102704-40-5
  • Formula Weight
    342.4
  • Molecular Formula
    C22H18N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (292.06 mM)
  • SMILES
    O=[N+](CC(C1=C(C2=CC=CC=C2)NC3=C1C=CC=C3)C4=CC=CC=C4)[O-]
  • Chemical Name
    3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Laprairie RB, et al. ACS Chem Neurosci. 2017 Jun 21;8(6):1188-1203.
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