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GAC0003A4

CAS No. 929492-71-7

GAC0003A4( —— )

Catalog No. M36252 CAS No. 929492-71-7

GAC0003A4 is a potent LXR inverse agonist with antitumor activity that inhibits the transcription of LXR proteins.GAC0003A4 degrades LXRβ proteins and inhibits the proliferation of PDAC cells in a dose-dependent manner.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 227 Get Quote
10MG 359 Get Quote
25MG 578 Get Quote
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Biological Information

  • Product Name
    GAC0003A4
  • Note
    Research use only, not for human use.
  • Brief Description
    GAC0003A4 is a potent LXR inverse agonist with antitumor activity that inhibits the transcription of LXR proteins.GAC0003A4 degrades LXRβ proteins and inhibits the proliferation of PDAC cells in a dose-dependent manner.
  • Description
    GAC0003A4 is an LXR inverse agonist that inhibits LXR transcriptional activity. GAC0003A4 also efficiently degrades LXRβ protein. GAC0003A4 has the potential to be used in advanced pancreatic cancer and other refractory malignancies.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Liver X Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    929492-71-7
  • Formula Weight
    340.42
  • Molecular Formula
    C20H24N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (367.19 mM; Ultrasonic )
  • SMILES
    C(=O)(C1=CC(OC)=CC(OC)=C1)N2CCN(CC2)C3=C(C)C=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Karaboga H, et al. Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity. ACS Chem Biol. 2020 Nov 20;15(11):2916-2928. ?
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