G15( —— )

Catalog No. M20708 CAS No. 1161002-05-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

G15
Note

Research use only, not for human use.
Brief Description

G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM).
Description

G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM).
In Vitro

Cell Proliferation Assay Cell Line:A549, H1793 cell lines Concentration:0.1, 1, 10 μM (combination with 10 nM E2)Incubation Time:2 days Result:Inhibited GPER-mediated proliferation stimulated by E2.Western Blot Analysis Cell Line:A549, H1793 cell lines Concentration:1 μM (combination with 10 nM E2 and 10 nM G1)Incubation Time:48 hours Result:Inhibited the response of GPER stimulated by E2 and G1.
In Vivo

Animal Model:Four-week-old female Kunming mice (Urethane-induced adenocarcinoma) Dosage:1.46 mg/kg (combination with E2, 0.09 mg/kg and fulvestrant (Ful), 2.4 mg/kg) Administration:Subcutaneous injection; twice a week for 14 weeks Result:The number of tumor nodules decreased in the E2+Ful+G15 group.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

GPER
Research Area

——
Indication

——

CAS Number

1161002-05-6
Formula Weight

370.24
Molecular Formula

C19H16BrNO2
Purity

>98% (HPLC)
Solubility

DMSO:41.67 mg/mL (112.55 mM)
SMILES

[H][C@]12CC=C[C@@]1([H])c1ccccc1N[C@H]2c1cc2OCOc2cc1Br
Chemical Name

(3aS4R9bR)-4-(6-bromo-13-benzodioxol-5-yl)-3a459b-tetrahydro-3H-cyclopenta[c]quinoline

1.Nayak T K Bologa C G Leitao A et al. In vivo effects of a GPR30 antagonist[J]. Nature Chemical Biology 2009 5(6):421-427.

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