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G007-LK
CAS No. 1380672-07-0
G007-LK ( G007LK; G007LK; G007 LK )
Catalog No. M17270 CAS No. 1380672-07-0
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 58 | In Stock |
|
| 5MG | 90 | In Stock |
|
| 10MG | 152 | In Stock |
|
| 25MG | 316 | In Stock |
|
| 50MG | 502 | In Stock |
|
| 100MG | 707 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameG007-LK
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NoteResearch use only, not for human use.
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Brief DescriptionG007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
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DescriptionG007-LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1/2 inhibitor. G007-LK displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice. G007-LK was first discovered by Dr. Stefan Krauss's team.
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SynonymsG007LK; G007LK; G007 LK
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PathwayEndocrinology/Hormones
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TargetAChR
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RecptorTNKS1;TNKS2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1380672-07-0
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Formula Weight529.96
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Molecular FormulaC25H16ClN7O3S
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Purity98%
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SolubilityDMSO : ≥ 30 mg/mL. 56.61 mM
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SMILESCS(=O)(=O)c1cnc(cc1)c1nnc(n1c1ccccc1Cl)/C=C/c1nnc(o1)c1ccc(cc1)C#N
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Chemical Name(E)-4-(5-(2-(4-(2-chlorophenyl)-5-(5-(methylsulfonyl)pyridin-2-yl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)benzonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Voronkov A,etal.Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor.J Med Chem. 2013 Apr 11;56(7):3012-23.
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