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Home - Products - Endocrinology/Hormones - AChR - G007-LK

G007-LK

CAS No. 1380672-07-0

G007-LK ( G007LK; G007LK; G007 LK )

Catalog No. M17270 CAS No. 1380672-07-0

G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    G007-LK
  • Note
    Research use only, not for human use.
  • Brief Description
    G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
  • Description
    G007-LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1/2 inhibitor. G007-LK displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice. G007-LK was first discovered by Dr. Stefan Krauss's team.
  • Synonyms
    G007LK; G007LK; G007 LK
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    TNKS1;TNKS2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1380672-07-0
  • Formula Weight
    529.96
  • Molecular Formula
    C25H16ClN7O3S
  • Purity
    98%
  • Solubility
    DMSO : ≥ 30 mg/mL. 56.61 mM
  • SMILES
    CS(=O)(=O)c1cnc(cc1)c1nnc(n1c1ccccc1Cl)/C=C/c1nnc(o1)c1ccc(cc1)C#N
  • Chemical Name
    (E)-4-(5-(2-(4-(2-chlorophenyl)-5-(5-(methylsulfonyl)pyridin-2-yl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)benzonitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Voronkov A,etal.Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor.J Med Chem. 2013 Apr 11;56(7):3012-23.
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