Fostemsavir ( BMS-663068; BMS 663068; Fostemsavir )

Catalog No. M19191 CAS No. 864953-29-7

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HNMR

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Product Name

Fostemsavir
Note

Research use only, not for human use.
Brief Description

BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
Description

Fostemsavir, also known as BMS-663068, is a oral, safe and effective HIV-1 attachment inhibitor. BMS-663068 is a prodrug of the small-molecule inhibitor BMS-626529, which inhibits human immunodeficiency virus type 1 (HIV-1) infection by binding to gp120 and interfering with the attachment of virus to CD4+ T-cells.
Synonyms

BMS-663068; BMS 663068; Fostemsavir
Pathway

Angiogenesis
Target

Adrenergic Receptor
Recptor

HIV-1
Research Area

Infection
Indication

——

CAS Number

864953-29-7
Formula Weight

583.5
Molecular Formula

C25H26N7O8P
Purity

98%
Solubility

DMSO : ≥ 100 mg/mL 171.38 mM H2O : 20 mg/mL 34.28 mM;
SMILES

COc1cnc(-n2cnc(C)n2)c2n(COP(O)(O)=O)cc(C(=O)C(=O)N3CCN(CC3)C(=O)c3ccccc3)c12
Chemical Name

(3-(2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl)-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl)methyl dihydrogen phosphate

1. Lalezari JP, et al. Lancet HIV. 2015 Oct;2(10):e427-37.

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