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Fluorobexarotene

CAS No. 1190848-23-7

Fluorobexarotene( —— )

Catalog No. M32926 CAS No. 1190848-23-7

Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 278 Get Quote
5MG 440 Get Quote
10MG 649 Get Quote
25MG 984 Get Quote
50MG 1334 Get Quote
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Biological Information

  • Product Name
    Fluorobexarotene
  • Note
    Research use only, not for human use.
  • Brief Description
    Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene.?
  • Description
    Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Retinoid Receptor
  • Recptor
    Retinoid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1190848-23-7
  • Formula Weight
    366.47
  • Molecular Formula
    C24H27FO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 36 mg/mL (98.23 mM )
  • SMILES
    CC1=CC2=C(C=C1C(=C)C1=CC(F)=C(C=C1)C(O)=O)C(C)(C)CCC2(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wagner CE, et al. Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J Med Chem. 2009 Oct?
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