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Filaminast

CAS No. 141184-34-1

Filaminast ( WAY-PDA-641;PDA-641;WAY-123641 )

Catalog No. M11714 CAS No. 141184-34-1

Filaminast (WAY-PDA-641;PDA-641;WAY-123641) is a potent and selective PDE4 inhibitor with IC50 of 420 nM, displays 36-fold selectivity over PDE3.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Filaminast
  • Note
    Research use only, not for human use.
  • Brief Description
    Filaminast (WAY-PDA-641;PDA-641;WAY-123641) is a potent and selective PDE4 inhibitor with IC50 of 420 nM, displays 36-fold selectivity over PDE3.
  • Description
    Filaminast (WAY-PDA-641;PDA-641;WAY-123641) is a potent and selective PDE4 inhibitor with IC50 of 420 nM, displays 36-fold selectivity over PDE3; significantly potentiates the relaxant effects of albuterol, reverses tracheal contractions induced by prostaglandin F2 alpha, leukotriene D4 or histamine in a biphasic manner.Asthma Phase 2 Discontinued
  • Synonyms
    WAY-PDA-641;PDA-641;WAY-123641
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Inflammation/Immunology
  • Indication
    Asthma

Chemical Information

  • CAS Number
    141184-34-1
  • Formula Weight
    292.34
  • Molecular Formula
    C15H20N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(\C)(=N/OC(=O)N)c1cc(c(cc1)OC)OC1CCCC1
  • Chemical Name
    1-(3-(Cyclopentyloxy)-4-methoxyphenyl)ethanone-(E)-O-(aminocarbonyl)oxime

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Heaslip RJ, et al. J Pharmacol Exp Ther. 1994 Feb;268(2):888-96.
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