Fidaxomicin( OPT-80 | PAR-101 )

Catalog No. M16356 CAS No. 873857-62-6

Fidaxomicin(OPT-80; PAR-101) is a?new class of narrow spectrum macrocyclic antibiotic drug.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	36	In Stock
25MG	49	In Stock
50MG	67	In Stock
100MG	113	In Stock
200MG	167	In Stock
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Biological Information

Product Name

Fidaxomicin
Note

Research use only, not for human use.
Brief Description

Fidaxomicin(OPT-80; PAR-101) is a?new class of narrow spectrum macrocyclic antibiotic drug.
Description

Fidaxomicin(OPT-80; PAR-101) is a?new class of narrow spectrum macrocyclic antibiotic drug, selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria.Bacterial Infection Approved(In Vitro):Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024?μg/mL).(In Vivo):Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis.
In Vitro

Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024?μg/mL).
In Vivo

Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis. Animal Model:Male Golden Syrian hamsters (80-100 g, Hamster model for pseudomembranous colitis)Dosage:0.2, 1, and 5 mg/kg Administration:Orally, once a day for 5 days, beginning 8 h after infectionResult:Completely prevented the lethality of the animals. Completely prevented the development of antibiotic-induced C. difficile colitis in hamsters at doses as low as 0.2 mg/kg.
Synonyms

OPT-80 | PAR-101
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

RNApolymerase
Research Area

Infection
Indication

Bacterial Infection

Chemical Information

CAS Number

873857-62-6
Formula Weight

1058.039
Molecular Formula

C52H74Cl2O18
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 33 mg/mL
SMILES

O=C(O[C@@H]1[C@@H](C)O[C@@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@H]3[C@@H](O)[C@@H](O)[C@H](OC(C(C)C)=O)C(C)(C)O3)/C(C)=C/C(C)=C/C[C@@H]([C@H](O)C)OC2=O)[C@@H](OC)[C@H]1O)C4=C(O)C(Cl)=C(O)C(Cl)=C4CC
Chemical Name

Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1