Farampator

Research use only, not for human use.

Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.

Farampator, also known as Org-24448; CX-691, is an AMPA receptor positive allosteric modulator potentially for the treatment of schizophrenia.(In Vivo):Farampator has potential in treating disorders characterised by cognitive deficits such as Alzheimer's disease and schizophrenia. CX691 attenuates a scopolamine-induced impairment of cued fear conditioning following acute administration (0.1 mg/kg p.o.) and a temporally induced deficit in novel object recognition following both acute (0.1 and 1.0 mg/kg p.o.) and sub-chronic (bi-daily for 7 days) administration (0.01, 0.03, 0.1 mg/kg p.o.). It also improves attentional set-shifting following sub-chronic administration (0.3 mg/kg p.o.). Farampator (500 mg) unequivocally improves short-term memory but appeares to impair episodic memory. Furthermore, it tends to decrease the number of switching errors in the CTMT. Drug-induced side effects (SEs) included headache, somnolence and nausea. Subjects with SEs has significantly higher plasma levels of farampator than subjects without SEs.

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Farampator has potential in treating disorders characterised by cognitive deficits such as Alzheimer's disease and schizophrenia. CX691 attenuates a scopolamine-induced impairment of cued fear conditioning following acute administration (0.1 mg/kg p.o.) and a temporally induced deficit in novel object recognition following both acute (0.1 and 1.0 mg/kg p.o.) and sub-chronic (bi-daily for 7 days) administration (0.01, 0.03, 0.1 mg/kg p.o.). It also improves attentional set-shifting following sub-chronic administration (0.3 mg/kg p.o.). Farampator (500 mg) unequivocally improves short-term memory but appeares to impair episodic memory. Furthermore, it tends to decrease the number of switching errors in the CTMT. Drug-induced side effects (SEs) included headache, somnolence and nausea. Subjects with SEs has significantly higher plasma levels of farampator than subjects without SEs.

Farampator | Org-24448 | CX-691

Immunology/Inflammation

Antiviral

AMPA

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211735-76-1

231.26

C12H13N3O2

>98% (HPLC)

DMSO : ≥ 34 mg/mL; 147.03 mM

O=C(N1CCCCC1)c1cc2nonc2cc1

1-(2,1,3-Benzoxadiazol-5-ylcarbonyl)piperidine

(-20℃)

With Ice Pack

≥ 2 years