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FRAX597
CAS No. 1286739-19-2
FRAX597 ( FRAX597; FRAX-597; FRAX 597 )
Catalog No. M17238 CAS No. 1286739-19-2
FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 125 | In Stock |
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| 25MG | 227 | In Stock |
|
| 50MG | 375 | In Stock |
|
| 100MG | 557 | In Stock |
|
| 500MG | 1197 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFRAX597
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NoteResearch use only, not for human use.
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Brief DescriptionFRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).
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DescriptionFRAX597 is a potent and selective inhibitor of the p21-activated kinases. FRAX597 inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture and displayed potent anti-tumor activity in vivo, impairing schwannoma development in an orthotopic model of NF2. These studies identify a novel class of orally available ATP-competitive Group I PAK inhibitors with significant potential for the treatment of NF2 and other cancers.
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SynonymsFRAX597; FRAX-597; FRAX 597
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PathwayAngiogenesis
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TargetEGFR
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RecptorPAK1; PAK2; PAK2; PAK3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1286739-19-2
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Formula Weight558.1
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Molecular FormulaC29H28ClN7OS
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Purity98%
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SolubilityDMSO : 14.29 mg/mL. 25.60 mM;H2O : < 0.1 mg/mL
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SMILESCCn1c2nc(ncc2cc(c1=O)c1c(cc(cc1)c1cncs1)Cl)Nc1ccc(cc1)N1CCN(CC1)C
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Chemical Name6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Licciulli S, et al. J Biol Chem. 2013, 288(4), 29105-29114.
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