FRAX486
CAS No. 1232030-35-1
FRAX486 ( FRAX486; FRAX-486; FRAX 486 )
Catalog No. M17208 CAS No. 1232030-35-1
FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 32 | In Stock |
|
5MG | 50 | In Stock |
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10MG | 84 | In Stock |
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25MG | 160 | In Stock |
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50MG | 295 | In Stock |
|
100MG | Get Quote | In Stock |
|
200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameFRAX486
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NoteResearch use only, not for human use.
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Brief DescriptionFRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.
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DescriptionFRAX486 is a potent p21-activated kinase (PAK) inhibitor (IC50 values are 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively). FRAX486 rescues seizures and behavioral abnormalities such as hyperactivity and repetitive movements, thereby supporting the hypothesis that a drug treatment that reverses the spine abnormalities can also treat neurological and behavioral symptoms. A single administration of FRAX486 is sufficient to rescue all of these phenotypes in adult Fmr1 KO mice, demonstrating the potential for rapid, postdiagnostic therapy in adults with FXS. FRAX486 ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence.
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SynonymsFRAX486; FRAX-486; FRAX 486
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PathwayOthers
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TargetOther Targets
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RecptorPAK1; PAK2 ; PAK3 ;PAK4
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1232030-35-1
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Formula Weight513.39
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Molecular FormulaC25H23Cl2FN6O
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Purity98%
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SolubilityDMSO : 21.2 mg/mL. 41.29 mM;
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SMILESCCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)Cl)Cl)NC4=CC(=C(C=C4)N5CCNCC5)F
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Chemical Name6-(2,4-Dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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