FM19G11
CAS No. 329932-55-0
FM19G11 ( HIF-1alpha/2alpha Inhibitor )
Catalog No. M28084 CAS No. 329932-55-0
Hypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 87 | Get Quote |
|
10MG | 160 | Get Quote |
|
25MG | 357 | Get Quote |
|
50MG | 530 | Get Quote |
|
100MG | 759 | Get Quote |
|
500MG | 1557 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameFM19G11
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NoteResearch use only, not for human use.
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Brief DescriptionHypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms.
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DescriptionHypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.(In Vitro):FM19G11 (500 nM) promotes oligodendrocyte differentiation under hypoxic conditions. FM19G11 (300 nM) significantly enhances the pro-apoptotic effect of temozolomide, whereas FM19G11 does not induce apoptosis. In hypoxic GBM-XD, hypoxic T98G, and normoxic T98G cells, FM19G11 (300 nM) significantly inhibited the mRNA level of O6-methylguanine DNA-methyltransferase via the HIF-1α pathway.(In Vivo):Intramedullary injection of FM19G11 improves locomotion in severe spinal cord injury and induces the expression of GAP43 and RIP at the injury.
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SynonymsHIF-1alpha/2alpha Inhibitor
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PathwayOthers
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TargetOther Targets
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Recptor5-HT1B;5-HT1D
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Research Area——
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Indication——
Chemical Information
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CAS Number329932-55-0
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Formula Weight463.4
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Molecular FormulaC23H17N3O8
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Purity>98% (HPLC)
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Solubility——
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SMILESCc1ccc(cc1)C(=O)COC(=O)c1cccc(NC(=O)c2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mu?oz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91.
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