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FGH-10019
CAS No. 1046045-61-7
FGH-10019( —— )
Catalog No. M21072 CAS No. 1046045-61-7
FGH-10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 244 | In Stock |
|
| 10MG | 354 | In Stock |
|
| 25MG | 592 | In Stock |
|
| 50MG | 843 | In Stock |
|
| 100MG | 1143 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameFGH-10019
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NoteResearch use only, not for human use.
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Brief DescriptionFGH-10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).
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DescriptionFGH-10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).
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In VitroTreatment of the CHO-K1 cells with analog FGH10019 decreases the percentage of the mature form of SREBP-2 (68 kDa) at lower concentrations than treatment with fatostatin. Densitometric analysis of the gels indicates that the IC50 of analog FGH10019 is approximately 1 μM, which is 5-10 times lower than the IC50 of fatostatin (appr 10 μM).
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In VivoFGH10019-treated chow is fed at a dose rate calculated to provide about 0.7 mg analog FGH10019 per day, at about 23 mg/kg body weight, to 5-wk-old male ob/ob mice weighing an average of appr 30 g. After 8 wk on the analog 24-treated chow, the mice gain 8-9 % less weight than control mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorSREBPs
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Research Area——
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Indication——
Chemical Information
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CAS Number1046045-61-7
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Formula Weight373.49
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Molecular FormulaC18H19N3O2S2
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Purity>98% (HPLC)
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SolubilityDMSO:38 mg/mL (101.74 mM)
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SMILESCCCc1cc(-c2nc(-c3ccc(NS(C)(=O)=O)cc3)cs2)ccn1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kamisuki S Shirakawa T Kugimiya A et al. Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins[J]. Journal of Medicinal Chemistry 2011 54(13):4923-4927.
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