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Home - Products - Metabolic Enzyme/Protease - Transferase - FDW028

FDW028

CAS No. 2768426-49-7

FDW028( —— )

Catalog No. M37123 CAS No. 2768426-49-7

FDW028 is a selective and potent fucosyltransferase 8 (FUT8) inhibitor with anti-tumor activity that drives B7-H3 lysosomal degradation via defucosylation and CMA pathways. FUT8 can be used to study metastatic colorectal cancer (mCRC).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 235 Get Quote
25MG 476 Get Quote
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Biological Information

  • Product Name
    FDW028
  • Note
    Research use only, not for human use.
  • Brief Description
    FDW028 is a selective and potent fucosyltransferase 8 (FUT8) inhibitor with anti-tumor activity that drives B7-H3 lysosomal degradation via defucosylation and CMA pathways. FUT8 can be used to study metastatic colorectal cancer (mCRC).
  • Description
    FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Transferase
  • Recptor
    Transferase | Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2768426-49-7
  • Formula Weight
    388.47
  • Molecular Formula
    C22H24N6O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (257.42 mM; Ultrasonic )
  • SMILES
    OC1=CC(=NC2=NC(=NN21)NCC3=CC=C(C=C3)CC)CNCC=4C=CC=CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang M, et al. FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer. Cell Death Dis. 2023 Aug 3;14(8):495.?
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