FB23-2 ( FTO Demethylase inhibitor FB23-2 )

Catalog No. M13595 CAS No. 2243736-45-8

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Product Name

FB23-2
Note

Research use only, not for human use.
Brief Description

FB23-2 is a potent, selective inhibitor of the mRNA N 6-methyladenosine (m 6A) demethylase FTO.
Description

FB23-2 is a potent, selective inhibitor of the mRNA N 6-methyladenosine (m 6A) demethylase FTO, directly bind to FTO, inhibits FTO demethylation of m6 A in RNA in vitro with IC50 of 2.6 uM; demonstrates significantly improved anti-proliferative activity on NB4 and MONOMAC6 cells with IC50 of 0.8-1.5 uM, compared with parental compound FB23; dramatically suppresses proliferation and promotes the differentiation/apoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells in vitro; FB23-2 significantly inhibits the progression of human AML cell lines and primary cells in xeno-transplanted mice.
Synonyms

FTO Demethylase inhibitor FB23-2
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

——
Indication

——

CAS Number

2243736-45-8
Formula Weight

392.24
Molecular Formula

C18H15Cl2N3O3
Purity

>98% (HPLC)
Solubility

DMSO : 62.5 mg/mL 159.34 mM
SMILES

O=C(NO)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)ON=C3C)C=C2Cl
Chemical Name

2-((2,6-dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-N-hydroxybenzamide

1. Huang Y, et al. Cancer Cell. 2019 Apr 15;35(4):677-691.e10.

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