FAUC-213

CAS No. 337972-47-1

FAUC-213( FAUC 213 | FAUC213 )

Catalog No. M24286 CAS No. 337972-47-1

FAUC-213 is a selective full antagonist of the dopamine D4 receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 140 In Stock
10MG 222 In Stock
25MG 447 In Stock
50MG 651 In Stock
100MG 888 In Stock
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Biological Information

  • Product Name
    FAUC-213
  • Note
    Research use only, not for human use.
  • Brief Description
    FAUC-213 is a selective full antagonist of the dopamine D4 receptor.
  • Description
    FAUC-213 is a selective full antagonist of the dopamine D4 receptor.
  • In Vitro
    FAUC 213 inhibits p5-HT1 (Ki=1.2 μM),p5-HT2 (Ki=0.52 μM),pα1 (Ki=0.27 μM).
  • In Vivo
    FAUC 213 (7.5-30 mg/kg; orally; single dose) significantly reduces this elevation in AMPH-induced locomotor hyper-activity only pre-treatment with 30 mg/kg. FAUC 213 significantly restores the prepulse inhibition (PPI) reduction caused by the apomorphine (APO) treatment with 30 mg/kg. Animal Model:Male adult Wistar rats weighing 300-350 g Dosage:7.5, 15, 30 mg/kg Administration:Orally; single dose Result:Significantly reduced this elevation in amphetamin (AMPH)-induced locomotor hyper-activity only pre-treatment with 30 mg/kg.
  • Synonyms
    FAUC 213 | FAUC213
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    D4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    337972-47-1
  • Formula Weight
    326.82
  • Molecular Formula
    C18H19ClN4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    C1CN(CCN1CC2=NN3C=CC=CC3=C2)C4=CC=C(C=C4)Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.St??el A, Brox R, Purkayastha N, Hübner H, Hocke C, Prante O, Gmeiner P. Development of molecular tools based on the dopamine D(3) receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior. Bioorg Med Chem. 2017 Jul 1;25(13):3491-3499. doi: 10.1016/j.bmc.2017.04.036. Epub 2017 Apr 29. PubMed PMID: 28495386; PubMed Central PMCID: PMC5512454.
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