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F16
CAS No. 36098-33-6
F16( (E)-4-(3-indolylvinyl)-N-methylpyridinium iodide )
Catalog No. M26683 CAS No. 36098-33-6
F16 inhibits the growth of neu-overexpressing cells and the proliferation of mammary epithelial.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 27 | Get Quote |
|
| 10MG | 42 | Get Quote |
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| 25MG | 87 | Get Quote |
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| 50MG | 159 | Get Quote |
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| 100MG | 232 | Get Quote |
|
| 200MG | 350 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameF16
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NoteResearch use only, not for human use.
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Brief DescriptionF16 inhibits the growth of neu-overexpressing cells and the proliferation of mammary epithelial.
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DescriptionF16 inhibits the growth of neu-overexpressing cells and the proliferation of mammary epithelial.(In Vitro):F16 arrests the cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells. F16 (3 μM) influences growth in human and mice cancer cell lines. F16 shows mitochondriotoxic property and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell.
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In VitroF16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines.F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells. Cell Proliferation Assay Cell Line:MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMGConcentration:3 μM Incubation Time:3 days/7 days Result:Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras-transgenic mice was not affected.
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In Vivo——
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Synonyms(E)-4-(3-indolylvinyl)-N-methylpyridinium iodide
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PathwayOthers
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TargetOther Targets
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RecptorIGF-1R| P-Akt (S473)| P-Akt (T308)| S6 Kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number36098-33-6
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Formula Weight362.21
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Molecular FormulaC16H15IN2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 31 mg/mL (85.59 mM)
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SMILES[I-].C[n+]1ccc(\C=C\c2c[nH]c3ccccc23)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang X, et al. Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice. NMR Biomed. 2014 Jul;27(7):843-52.
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