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Home - Products - Endocrinology/Hormones - 5-HT Receptor - F-11440

F-11440

CAS No. 179756-58-2

F-11440 ( Eptapirone )

Catalog No. M12716 CAS No. 179756-58-2

A potent, selective 5-HT1A receptor agonist with Ki of 4.8 nM, pKi of 8.33.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    F-11440
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective 5-HT1A receptor agonist with Ki of 4.8 nM, pKi of 8.33.
  • Description
    A potent, selective 5-HT1A receptor agonist with Ki of 4.8 nM, pKi of 8.33; shows ≥shows 100-fold higher affinity for the other serotonin receptor subtypes, and has no detectable antidopaminergic activity and antihistaminergic activity; decreases the forskolin-induced increase in AMP in HeLa cells expressing human 5-HT1A receptors; produces anxiolytic- and antidepressant-like effects in animal models.Anxiety Phase 1 Discontinued
  • Synonyms
    Eptapirone
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT1A
  • Research Area
    Neurological Disease
  • Indication
    Anxiety

Chemical Information

  • CAS Number
    179756-58-2
  • Formula Weight
    345.40
  • Molecular Formula
    C16H23N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 6 mg/mL (Need ultrasonic)
  • SMILES
    O=C(N1C)N(CCCCN2CCN(C3=NC=CC=N3)CC2)N=CC1=O
  • Chemical Name
    1,2,4-Triazine-3,5(2H,4H)-dione, 4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Koek W, et al. J Pharmacol Exp Ther. 1998 Oct;287(1):266-83.
2. Prinssen EP, et al. Eur J Pharmacol. 2002 Oct 25;453(2-3):217-21.
3. Pauwels PJ, et al. J Pharmacol Exp Ther. 2003 Nov;307(2):608-14.
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