Cart
sales@molnova.com
Evocalcet
CAS No. 870964-67-3
Evocalcet( KHK7580 )
Catalog No. M22494 CAS No. 870964-67-3
Evocalcet has an activating effect on the calcium-sensing receptor (CaSR).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 63 | In Stock |
|
| 10MG | 96 | In Stock |
|
| 25MG | 194 | In Stock |
|
| 50MG | 309 | In Stock |
|
| 100MG | 447 | In Stock |
|
| 500MG | 972 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameEvocalcet
-
NoteResearch use only, not for human use.
-
Brief DescriptionEvocalcet has an activating effect on the calcium-sensing receptor (CaSR).
-
DescriptionEvocalcet has an activating effect on the calcium-sensing receptor (CaSR).
-
In Vitro——
-
In VivoAnimal Model:Male Sprague Dawley chronic kidney disease (CKD) rats with adenine induced secondary hyperparathyroidism (SHPT)Dosage:0.03 and 0.3 mg/kg Administration:Oral Administration; 0.03 and 0.3 mg/kg, once Result:Decreased the serum PTH and Ca levels at a dose of 0.3 mg/kg.
-
SynonymsKHK7580
-
PathwayGPCR/G Protein
-
TargetCaSR
-
RecptorCaSR
-
Research AreaCancer
-
IndicationParathyroid CarcinomaPrimary Hyperparathyroidism
Chemical Information
-
CAS Number870964-67-3
-
Formula Weight374.48
-
Molecular FormulaC24H26N2O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:30 mg/mL (80.11 mM; Need ultrasonic and warming)
-
SMILESC[C@@H](N[C@H]1CCN(C1)c1ccc(CC(O)=O)cc1)c1cccc2ccccc12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Tanimura, Shinji, et al. Pharmaceutical composition containing aryl alkyl amine compound. WO 2017061621 A1.
molnova catalog
related products
-
Cinacalcet
A calcimimetic agent that acts as an allosteric activator of CaSR.
-
Tecalcet hydrochlori...
Tecalcet (R-568;NPS R-568;KRN-568;NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.
-
NPS-2143 hydrochlori...
A potent, selective and orally active CaSR antagonist with IC50 of 43 nM; does not inhibit cytoplasmic Ca2+ responses to glutamate in HEK 293 cells engineered to express mGluRs and GABAB receptors.
