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Etomoxir

CAS No. 124083-20-1

Etomoxir ( Etomoxir; B 807-54;B80754; B-80754; (R)-(+)-Etomoxir )

Catalog No. M10974 CAS No. 124083-20-1

An irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) that inhibits fatty acid β-oxidation in rat liver with IC50 of 5-20 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Etomoxir
  • Note
    Research use only, not for human use.
  • Brief Description
    An irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) that inhibits fatty acid β-oxidation in rat liver with IC50 of 5-20 nM.
  • Description
    An irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) that inhibits fatty acid β-oxidation in rat liver with IC50 of 5-20 nM; affects ketogenesis, cholesterol synthesis, and gluconeogenesis both in vitro and in vivo; decreases viability in LNCaP, VCaP, and patient-derived benign and prostate cancer cells, associated with decreased AR expression, decreased mTOR signaling, and increased caspase-3 activation; decreases xenograft growth in mice.Heart Failure Phase 2 Discontinued
  • Synonyms
    Etomoxir; B 807-54;B80754; B-80754; (R)-(+)-Etomoxir
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    124083-20-1
  • Formula Weight
    326.82
  • Molecular Formula
    C17H23ClO4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C([C@]1(CCCCCCOC2=CC=C(Cl)C=C2)OC1)OCC
  • Chemical Name
    2-Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lopaschuk GD, et al. Circ Res. 1988 Dec;63(6):1036-43.
2. Kruszynska YT, et al. Biochem Pharmacol. 1987 Nov 15;36(22):3917-21.
3. Schlaepfer IR, et al. Mol Cancer Ther. 2014 Oct;13(10):2361-71.
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