Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - Other Targets - Etiocholanone

Etiocholanone

CAS No. 53-42-9

Etiocholanone( —— )

Catalog No. M24515 CAS No. 53-42-9

Etiocholanolone (5β-Androsterone) is the excreted?metabolite?of testosterone and has anticonvulsant activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 49 In Stock
5MG 60 In Stock
10MG 90 In Stock
25MG 163 In Stock
50MG 245 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Etiocholanone
  • Note
    Research use only, not for human use.
  • Brief Description
    Etiocholanolone (5β-Androsterone) is the excreted?metabolite?of testosterone and has anticonvulsant activity.
  • Description
    Etiocholanolone (5β-Androsterone) is the excreted?metabolite?of testosterone and has anticonvulsant activity. Etiocholanolone is a less potent?neurosteroid positive allosteric modulator?(PAM) of the?GABAA?receptor than its?enantiomer form.
  • In Vitro
    Etiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it isineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect).
  • In Vivo
    Etiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50?values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Other Targets
  • Recptor
    GABAA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    53-42-9
  • Formula Weight
    290.44
  • Molecular Formula
    C19H30O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:97 mg/mL?(333.97 mM;?Need ultrasonic)
  • SMILES
    C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC1)[C@H]3C[C@@H]1O)C2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ping Li,et al. Natural and Enantiomeric Etiocholanolone Interact With Distinct Sites on the Rat alpha1beta2gamma2L GABAA Receptor. Mol Pharmacol. 2007 Jun;71(6):1582-90.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Etomidate hydrochlor...

    Etomidate hydrochloride is a potent agonist of GABAA receptor. It is a neurological drug and effective parenteral medication and has the potential for management of endogenous hypercortisolaemia.

  • Lotilaner

    Lotilaner is a parasiticide. It is used as a potent non-competitive antagonist of insects GABACl receptors.

  • 2'MeO6MF

    2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.

Sign In Join Free