Ercalcidiol( 25-hydroxy Vitamin D2 )

Catalog No. M26679 CAS No. 21343-40-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Ercalcidiol
Note

Research use only, not for human use.
Brief Description

Ercalcidiol is a metabolite of vitamin D2 and can be used in monitoring vitamin D therapy.
Description

Ercalcidiol is a metabolite of vitamin D2 and can be used in monitoring vitamin D therapy.(In Vitro):The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and Ercalcidiol binds less well to the vitamin D binding protein, making Ercalcidiol less potent and required much higher doses than vitamin D3 .
In Vitro

Differentiation between Ercalcidiol (25(OH)D2) and 25(OH)D3 is important for monitoring vitamin D therapy, as vitamin D2 is the predominant prescription form. The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and it binds less well to the vitamin D binding protein, making it less potent and, therefore, required to be administered at much higher doses than vitamin D3. Some currently used assays have a diminished capacity to detect Ercalcidiol, which can lead to dangerous overdosing when attempting to monitor therapy with vitamin D2.
In Vivo

——
Synonyms

25-hydroxy Vitamin D2
Pathway

Proteasome/Ubiquitin
Target

Endogenous Metabolite
Recptor

RUVBL1/2
Research Area

——
Indication

——

CAS Number

21343-40-8
Formula Weight

412.658
Molecular Formula

C28H44O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 200 mg/mL (484.67 mM)
SMILES

[H][C@@]12CC[C@H]([C@H](C)\C=C\[C@H](C)C(C)(C)O)[C@@]1(C)CCC\C2=C/C=C1/C[C@@H](O)CCC1=C
Chemical Name

——

1.Assimon VA, et al. CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity. ACS Chem Biol. 2019 Feb 15;14(2):236-244.

Calculator

molnova catalog