
Eprosartan
CAS No. 133040-01-4
Eprosartan( —— )
Catalog No. M34068 CAS No. 133040-01-4
Eprosartan (SKF-108566J free base) is a selective, competitive nonpeptide angiotensin II receptor antagonist with high affinity for AT1 receptor subtypes, used as an antihypertensive agent.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 37 | Get Quote |
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10MG | 61 | Get Quote |
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25MG | 97 | Get Quote |
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50MG | 141 | Get Quote |
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100MG | 206 | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameEprosartan
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NoteResearch use only, not for human use.
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Brief DescriptionEprosartan (SKF-108566J free base) is a selective, competitive nonpeptide angiotensin II receptor antagonist with high affinity for AT1 receptor subtypes, used as an antihypertensive agent.
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DescriptionEprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
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In VitroEprosartan (SKF-108566J) inhibits [125I]AII binding to human liver membranes (IC50 of 1.7 nM) and to rat mesenteric artery membranes (IC50 of 1.5 nM). In rabbit aortic smooth muscle cells, Eprosartan caused a concentration-dependent inhibition of AII-induced increases in intracellular Ca2+ levels.
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In VivoIn conscious normotensive rats, i.v. administration of Eprosartan (0.01-0.3 mg/kg) produced dose-dependent parallel shifts in the AII pressor dose-response curve. Administration of Eprosartan (3-10 mg/kg intraduodenally or intragastrically to conscious normotensive rats resulted in a dose-dependent inhibition of the pressor response to AII (250 ng/kg, i.v.). At 10 mg/kg, i.d., significant inhibition of the pressor response to AII was observed for 3 hr.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetRAAS
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RecptorRAAS
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Research Area——
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Indication——
Chemical Information
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CAS Number133040-01-4
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Formula Weight424.51
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Molecular FormulaC23H24N2O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (294.46 mM; Ultrasonic )
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SMILESCCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(cc1)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. R M Edwards, et al. Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther. 1992 Jan;260(1):175-81.?
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