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Enzalutamide

CAS No. 915087-33-1

Enzalutamide ( MDV3100;MDV-3100;MDV 3100 )

Catalog No. M16573 CAS No. 915087-33-1

An androgen-receptor (AR) antagonist with IC50 of 36 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 38 In Stock
10MG 52 In Stock
25MG 61 In Stock
50MG 87 In Stock
100MG 140 In Stock
200MG 177 In Stock
500MG 259 In Stock
1G 397 In Stock
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Biological Information

  • Product Name
    Enzalutamide
  • Note
    Research use only, not for human use.
  • Brief Description
    An androgen-receptor (AR) antagonist with IC50 of 36 nM.
  • Description
    An androgen-receptor (AR) antagonist with IC50 of 36 nM; reduces the efficiency of AR nuclear translocation, and impairs both DNA binding to androgen response elements and recruitment of coactivators; induces tumor regression in mouse models of castration-resistant human prostate cancer; orally available.Prostate cancer Approved
  • Synonyms
    MDV3100;MDV-3100;MDV 3100
  • Pathway
    Endocrinology/Hormones
  • Target
    Androgen Receptor (AR)
  • Recptor
    AndrogenReceptor
  • Research Area
    Cancer
  • Indication
    Prostate Cancer

Chemical Information

  • CAS Number
    915087-33-1
  • Formula Weight
    464.44
  • Molecular Formula
    C21H16F4N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NC)C1=CC=C(N(C(N2C3=CC=C(C#N)C(C(F)(F)F)=C3)=S)C(C)(C)C2=O)C=C1F
  • Chemical Name
    Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tran C, et al. Science. 2009 May 8;324(5928):787-90.
2. Richards J, et al. Cancer Res. 2012 May 1;72(9):2176-82.
3. Scher HI, et al. N Engl J Med. 2012 Sep 27;367(13):1187-97.
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